@conference {40335,
	title = {Non-milk constituents in replacers for calf rearing},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {51},
	year = {1991},
	month = {Jan},
	pages = {323-326},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {This study was carried out to investigate central nervous system  pathways which may be involved in the depression of food intake  exhibited by parasitised lambs.   Ten lambs with intake depression (c.20\%; p<0.05); as a result of chronic  infection with 4000 T.colubriformis larvae/day together with 10  non-infected animals were used in a factorially designed experiment.  The factors were a 24 h fast or no fasting followed by; saline solution  (control), or 0.6 mg/kg brotizolam (blocks satiety signals at the  ventromedial hypothalamus), or 0.125 mg/kg of naloxone (an opioid  antagonist), all in a 2 ml volume given i.v. immediately prior to  feeding.   Trickle infection depressed mean daily intake by 20\% (p<0.05), likewise  short term intake was depressed by infection (p<0.05). Fasting  stimulated both short term and daily intake by approximately 100\%  (p<0.001) and 12\% (p<0.05) respectively. Naloxone depressed cumulative  intake for up to 2 h (p<0.01 - p<0.001) while brotizolam stimulated  intake at both 60 and 120 minutes (p<0.001).   These results show that opioid signals stimulate food intake in lambs  and that fasting will overcome the effects of parasitism on appetite in  the short term. A lack of opioid signals may be a factor in parasite  induced food intake depression.  },
	issn = {1176-5283},
	author = {Wilson GF and Brookes IM and Lynch GA and Billington AC}
}
