@conference {40215,
	title = {Development and use of gene transfer in New Zealand},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {50},
	year = {1990},
	month = {Jan},
	pages = {191-196},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {A major factor in the reduction of growth in parasitized lambs   is the depression in food intake by a mechanism not yet understood.     Investigation of the pattern of eating has shown that parasitized lambs   have a lower (35\%) cumulative intake, especially within the first hour of   feeding, which return to a control level on drenching. The importance   of two factors which may moderate intake depression, the activity of   ventromedial hypothalamus (VMH) and elevated cholecystokinin (CCK), were   investigated.     Four animals with intake depression (approximately 40\% P<0.05) as a   result of continuous infection with 4000 T.colubriformis per day   for 12 weeks together with 4 control animals received, in a replicated   latin square design 0, 1, 2 and 4ml i.v. of a compound   (brotizolam) used to block the satiety effect at the VMH. Intake   increased (P<0.05) within the first hour of feeding of both parasitized   and control animals (approximately 2.6 and 1.9 times, respectively).   Four similarly infected and 4 control lambs were given varying doses of   a potent antagonist of peripheral CCK action without effect on food   intake. These results suggest that depression of food intake in   parasitized lambs appears to involve central satiety signals and not   peripheral CCK.    },
	issn = {1176-5283},
	author = {Bullock DW}
}
