@conference {40964,
	title = {Finding QTL{\textquoteright}s without markers: experience with FINDGENE.},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {57},
	year = {1997},
	month = {Jan},
	pages = {290-294},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {FlNDGENE  is  a  mixed  inheritance  model  computer  program  which  can  analyse  extensive  animal  pedigrees.  It  partitions  the observed  variance  into  fixed  effects.  polygenic  inheritance,  a  two  allele  major  locus  effect  and  a residual  envimnmental  variance.  It do-es  not  require  genotype  information.  Data  from  three  New  Zealand  sheep  experiments  where  faecal  nematode  egg  count  (FEC) information  had been  collected  were  examined  by  this  method.  They  included  a long  term  selection  experiment  for  FEC  in  Rornneys at Wallaceville,  another  in  Perendales  at Ruakura,  and  a randomly  mated  Coopworth  flock  at Woodlands  Research  Station.  All  PEC traits  were  initially  transformed  using  the  function  log.(x+lOO).  The  final  model  included  the  effect  of  sex/year  contemporary  group, birthday  and polygenic  inheritance  in addition  to a 2 allele  Mendelian  gene effect.  Results  from  all  three  data  sets  suggested a  dominant a{\textquoteright}utosomal  gene  for  host susceptibility  was  affecting  strongyle  PEC  values  in  the  summer/autumn  period  with  estimates  of  0.37,0.69 and 0.72  log  eggs/g  for  the  single  allele  effect  from  Romney,  Perendale  and Coopworth  flocks  respectively.  Corresponding  values  for dominance  were  0.47,0.44  and 0.88  log eggs/g  with  susceptible  allele  frequency  0.14.0.55  and 0.69.  When  considered  together,  these results  suggest  that  at  least  one  QTL  is  affecting  the  development  of  host  resistance  to  internal  parasites  in  young  sheep.  The identification  and  characterisation  of  this  QTL  may  result  in  useful  novel  methods  of  internal  parasite  control.},
	issn = {1176-5283},
	author = {McEwan JC and Morris CA and Bisset SA and Kerr RJ}
}
