@conference {40744,
	title = {Ovarian characteristics in Inverdale ewes heterozygous (I+) and homozygous (II) for the Inverdale gene (FecX)},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {55},
	year = {1995},
	month = {Jan},
	pages = {301-303},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {The Inverdale gene (FecX) affects ovarian development, during both  foetal and adult life. There is evidence for affects on germ-cells, the  follicle and the corpus luteum. In I+ewes, follicles ovulate at a small  diameter with fewer granulosa cells and the resulting corpora lutea are  individually smaller compared to those in control (++) animals. This  appears to be due to the granulosa cells in I+ follicles being more  responsive to follicle-stimulating hormone (FSH) and acquiring receptors  for luteinising hormone (LH) earlier than in cells from ++ ewes. These  differences between I+ and ++ ewes in ovarian characteristics occur in  the absence of any obvious differences in the peripheral plasma  concentrations of FSH and LH or the ovarian secretion rates of inhibin,  oestradiol and progesterone. In II animals, ovarian follicular growth  is impaired at the primary stage of growth during foetal, neonatal and  adult life. No normal follicles beyond this stage of growth have been  observed. II animals also have castrate levels of FSH and LH and  undetectable plasma levels of ovarian steroid or inhibin. In ~35\% of II  animals, abnormal surface-visible structures have been observed with a  morphology consistent with that of a sertoli-cell or sex-chord stromal  tumour. These structures, which secrete inhibin, appear to develop from  clusters of oocyte-free follicles.   },
	issn = {1176-5283},
	author = {McNatty KP and Smith P and Hudson NL and Lun S and Heath D and Shackell G and Corrigan K}
}
