The evidence for the fetal origins of adult disease (diabetes, cardiovascular) is reviewed. There is evidence of a disturbed endocrine communication between the hypothalamus, adipose tissue and the endocrine pancreas in the pathogenesis of programming-induced obesity. Hypercaloric nutrition during postnatal life greatly amplifies prenatal effects on metabolic abnormalities, obesity, overeating and diminished exercise behaviour. Fetal programming research offers a novel approach to investigate the mechanistic basis of metabolic disorders.

SO, Krechowec, MH Vickers, and BH Breier

Proceedings of the New Zealand Society of Animal Production, Volume 64, Hamilton, 24-29, 2004
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